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However, the incidence of HPV-related oropharyngeal and anal cancers has been increasing and oropharyngeal squamous cell carcinoma was recently reported to have become the most common HPV-associated cancer in the United States (361)Van Dyne EA, Henley SJ, Saraiya M, Thomas CC, Markowitz LE, Benard VB

That means not only will companies that can't meet the deadline see their products removed from store shelves, but that even those that do submit on time may find their products at risk of being removed if the agency dawdles in reviewing the applications as it did with the IQOS

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